The model, 30, whose real name is Amber Levonchuck, filed for divorce from the Pittsburgh rapper on Tuesday after a little more than a year of marriage, according to court documents obtained by the Los Angeles Times.
She cited irreconcilable differences as the reason for the split and is seeking full legal and physical custody of their son, Sebastian "The Bash" Taylor Thomaz, whom they welcomed in February 2013.
Wiz, 27, real name Cameron Thomaz, can get visitation, the documents said.
The couple has a prenuptial agreement, which likely addresses the terms of her spousal support, though she's asking him to pay her attorneys' fees.
The two began dating in early 2011 and got engaged in March 2012. They got hitched on July 8, 2013, and had a grand ceremony the following month. She listed the date of separation as Sept. 22.
On their first anniversary, Rose revealed a snapshot from their secret nuptials and a sweet greeting to her husband.
"Today was the day we said our vows before God and our Family," she wrote, sharing a pic of them and their son in their unique wedding regalia. "I knew as soon as I met u, u were the one for me sweetheart. Happy 1 year anniversary @mistercap and many more to come"
A few weeks later, she shared another tender snapshot wishing her man a happy birthday.
"Happy 27th Birthday @mistercap I'll love u forever. Hope this year is an amazing one for u sweetheart," she wrote.
It's unclear why the couple called it quits, but rumors about infidelity have been making their way into the tabloids.